Antibody Modeling / Developability / Liability / Aggregation
Antibody candidates often have poor biophysical properties and/or chemical liabilities that cause downstream developability issues. In this demonstration, we will model a mouse antibody and identify liability motifs using such as glycosylation PTM sites and we will propose statistically appropriate mutations. We will then model a panel of 14 IgG4 candidates and select one for improved developability in terms of aggregation and solubility using high-throughput antibody modeling and property calculations.