MOE Workshop Series

North America

May 11, 2016

Location: The Harvard Faculty Club
20 Quincy Street, Cambridge, MA, 02138, United States

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 Protein Homology Modeling
The course covers protein alignments and homology modeling in MOE. The homology modeling section covers the complete sequence to structure workflow, including template searching, query alignment, adjustment of the alignment between the sequence and the template, homology model building and refinement, along with applications for assessing model quality. Refinement of protein loops and loop conformations using the Loop Modeler and LowModeMD conformational searching will be discussed. Protein contacts will be evaluated after aligning and super-positioning protein multimers. A method for superposing proteins that is strictly based on structural motifs will be described.

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Raul Alvarez
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