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December 05, 2019
 
08h00-08h30
Welcome Refreshments / Registration Opens (Check-In and Badge Pick-Up)
08h30-10h00
Workshop:
Structure-Based Drug Design and Docking 
Structure Family Search / Protein-Ligand Interaction Fingerprints / MOE Project / Docking / Pharmacophore Modeling
10h00-10h30
Morning Break
10h30-12h00
Workshop:
De Novo Design and Library Generation 
Scaffold Replacement / MedChem Transformations / Reaction-Guided Library Enumeration / R-Group Screening
12h00-13h00
Workshop Lunch
13h00-13h30
Registration (Check-In and Badge Pick-Up)
13h30-13h35
Opening Remarks: Alain Deschenes, CCG
Chair: Tony Siu, Merck
13h35-14h05
Fragment Hits and Leads: More Than Meets the Eye
Fabrizio Giordanetto, Head Medicinal Chemistry, D.E. Shaw Research
14h05-14h35
A Small-Molecule Inhibitor of C5 Complement Protein
Keith Jendza, Scientific Technical Leader I, Novartis
14h35-15h05
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
Joy Yang, Scientist, Pfizer
15h05-15h35
Computational Evaluation of PROTAC-Mediated Protein Degradation: Case Studies and Recent Developments
Michael Drummond, Scientific Applications Manager, Chemical Computing Group
15h35-16h05
Afternoon Break
Chair: Matt Lucas, Black Diamond Therapeutics
16h05-16h35
An Iterative Scaffold-Hopping Strategy for The Design of Selective PI3K-δ Inhibitors
Xavier Fradera, Associate Principal Scientist, Merck
16h35-17h05
Ligand-based Design of a Selective Antagonist of TRPA1 That Demonstrates Potent In Vivo Activity
Laurie Schenkel, Associate Director, Ribon Therapeutics
17h05-17h35
Discovery of JAK1 Selective Kinase Inhibitor, AZD4205
Qibin Su, Associate Principal Scientist, AstraZeneca
17h35-18h05
Multiparameter Optimization in Drug Discovery
Istvan Enyedy, Principal Scientist, Biogen
18h05-18h10
Closing Remarks: Chris Williams, CCG
18h10-19h10
Social Reception