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We are pleased to announce that the next CCG North American UGM and Conference is returning to an "in-person" format and will take place on June 21-24 in Montreal, Canada. This is a 4-day event, consisting of workshops, scientific presentations, and a poster session as well as social activities including receptions and a conference dinner.

TUESDAY, June 21 - Workshops
DAY 1
08:00
Registration Opens
08:30-09:00
Welcome Refreshments
09:00-12:00
Ligand-Based Drug Design and SAR Analysis 
MOEsaic / R-Group Profiles and Analysis / MMP Analysis / Similarity and Substructure Searching / Descriptor Calculations / Conformational Searching / Molecular Alignments / Pharmacophore Modeling and Searching
09:00-12:00
Organizing Protein Structural Families and Data Mining 
MOE project / specialized protein families / project search / Organizing and centralizing project data / protein family modeling
09:00-12:00
Introduction to SVL 
SVL Concepts / Scripts for Moe/Batch / Test New Ideas/Hypotheses / Customize MOE / Programming Techniques / Window Toolkit / Descriptors and Fingerprints / Interactive Problem Solving
12:00-13:30
Lunch Break
13:30-16:30
Fragment-Based Drug Design 
Scaffold Replacement / Medicinal Chemistry Transformations / Fragment Linking / R-Group Screening / Ligand Growing / Pharmacophores / Fragment Databases
13:30-16:30
Peptide Modeling, Conformational Searching and Docking 
Structure preparation / Non-natural amino acids / Conformational searching / Distance restraints / Peptide-protein docking / Protein-ligand interaction fingerprints
13:30-16:30
X-Ray Crystallography: Structure Preparation, Electron Density and Solvent Analysis 
Structure Preparation / Side-Chain Rotamer Exploration / Electron Density Maps / Solvent Analysis with 3D-RISM
WEDNESDAY, June 22 - Workshops & Poster Session
DAY 2
08:30-09:00
Welcome Refreshments
09:00-12:00
Advanced Structure-Based Drug Design 
Pharmacophore Modeling / Docking / Fragment-based Design / Scaffold Replacement / R-Group Screening / Project Search / Protein-Ligand Interaction Fingerprints
09:00-12:00
Antibody Modeling and Protein Engineering 
Protein Engineering / Protein Properties / Developability / Hot Spot Analysis / Antibody Modeling / Humanization / Molecular Surfaces
09:00-12:00
Cheminformatics and QSAR 
MOE databases / Calculated Descriptors / Fingerprints / QSAR Modeling / Binary QSAR / Similarity Searching / Consensus Modeling
12:00-13:30
Lunch Break
13:30-16:30
Small Molecule Virtual Screening 
Virtual Screening Compound Libraries / Descriptors, Fingerprints and QSPR Modeling / Pharmacophore Modeling / Template-based Docking / Compound Design
13:30-16:30
Biologics: Protein Alignments, Modeling and Docking 
Protein Alignments and Superposition / Loop and Linker Modeling / Homology Modeling / Protein- Protein Docking / Protein Solubility Analysis / 2D Hot Spot Mapping / PLIF / Biologics QSAR Modeling
13:30-16:30
PSILO: A Protein-Ligand Structural Information Repository for Searching and Managing Public and Private Data 
Macromolecular repository / 3D query searching / pocket similarity / display electron density / central repository / Specialized protein databases
18:30-20:30
Opening Reception & Poster Session
20:45
Optional Montreal Walking Tour
THURSDAY, June 23 - Scientific Presentations
DAY 3
08:30-09:00
Welcome Refreshments
09:00-09:05
Opening Remarks
09:05-09:35
Artificial Intelligence in Drug Discovery – Revolution, Evolution, or Complete Nonsense 
Pat Walters, Senior Vice President Computation, Relay Therapeutics
09:35-10:05
Building a Knowledge Base to Unlock Molecular Machines 
Cen Gao, Director, Head of CADD, MOMA Therapeutics
10:05-10:35
One Hundred Fifteen Years of Solitude SVL 
David Lawson, Senior Director, Structural Chemistry, Mirati Therapeutics
10:35-11:05
Morning Break
11:05-11:35
Ensemble Docking with MOE: Very High Throughput and Highly Enriched Ligand Screening 
Jerome Baudry, Pei-Ling Chan Eminent Scholar and Professor, University of Alabama
11:35-12:05
The Use of Trajectory Data from Long-Timescale Molecular Dynamics Simulations in Virtual Screening 
Miklos Feher, Senior Research Scientist, D.E. Shaw Research
12:05-12:35
Database autoph4: Pharmacophore Analysis of Multiple Protein Structures 
Chris Williams, Director of Scientific Support, Principal Scientist, Chemical Computing Group
12:35-14:00
Lunch Break
14:00-14:30
Mining Minima Comes of Age: Integration of the VM2 Protein-Ligand Free Energy Method and MOE 
Michael Gilson, Professor, Biomolecular theory and simulation, University of California San Diego, and Co-Founder, VeraChem LLC
14:30-15:00
Positional Analogue Scanning with Amber GPU-TI 
Yuan Hu, Associate Principal Scientist, Alkermes
15:00-15:30
Incorporating Large Scale QM in Ligand Design Pipelines 
Monika Williams, Scientist II, Frontier Medicines
15:30-16:00
Afternoon Break
16:00-16:30
An Iterative Scaffold-Hopping Strategy for The Design of Selective PI3K-δ Inhibitors 
Xavier Fradera, Senior Principal Scientist, Blueprint Medicines
16:30-17:00
Love Drug Discovery in the Time of Cholera COVID
José Duca, Global Head of Computer-Aided Drug Discovery, Novartis
18:30-22:00
Drinks Reception and Conference Dinner at Gibbys
FRIDAY, June 24 - Scientific Presentations
DAY 4
08:30-09:00
Welcome Refreshments
09:00-09:30
Reverse Fingerprinting: Application to Motif Detection and Pharmacophore Query Generation 
Chris Williams, Director of Scientific Support, Principal Scientist, Chemical Computing Group
09:30-10:00
A General Survey of Characteristics of 89 Antibody-based Biotherapeutics  
Kyle Martin, Postdoctoral Researcher, Boehringer Ingelheim
10:00-10:30
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening 
Essam Metwally, Principal Scientist, Merck & Co., Inc.
10:30-11:00
Morning Break
11:00-11:30
Enhancing Subunit Interactions Through Iterative Protein Design Using Protein-Protein Docking in MOE 
Nancy Deng, Director, Computational Chemistry, ChemPartner
11:30-12:00
MOE Antibody Database: Structural Bioinformatics for Antibody Research 
Prabakaran Ponraj, Large Molecule Research, Senior Principal Scientist, Sanofi
12:00-12:30
Structure-Based Charge Calculations for Predicting Properties and Profiling Antibody Therapeutics 
Nels Thorsteinson, Director of Biologics, Chemical Computing Group
12:30-14:00
Lunch Break
14:00-14:30
Hunting for Relevant Preclinical Properties of Successful Biotherapeutics: The Quest Continues 
Vanita D. Sood, Global Head of Drug Disposition & Design Discovery & Development Technologies, EMD Serono
14:30-15:00
Next Generation Fc Scaffold for Multispecific Antibodies 
Fernando Garces, Director Protein Therapeutics, Gilead Sciences
15:00-15:30
Consensus Protein Design of ScFvs
Sandeep Kumar, Distinguished Research Fellow (Biotherapeutics) and Group Leader, Boehringer Ingelheim
15:30-15:40
Closing Remarks
15:40-16:30
Closing Reception