December 05, 2019
 
08:00-08:30
Welcome Refreshments / Registration Opens (Check-In and Badge Pick-Up)
08:30-10:00
Workshop: Structure Based Drug Design and Docking
Structure Family Search / Protein-Ligand Interaction Fingerprints / MOE Project / Docking / Pharmacophore Modeling
10:00-10:30
Morning Break
10:30-12:00
Workshop: De Novo Design and Library Generation
Scaffold Replacement / MedChem Transformations / Reaction-Guided Library Enumeration / R-Group Screening
12:00-13:00
Workshop Lunch
13:00-13:30
Registration (Check-In and Badge Pick-Up)
13:30-13:35
Opening Remarks: Alain Deschenes, CCG
Chair: Tony Siu, Merck
13:35-14:05
Fragment Hits and Leads: More Than Meets the Eye 
Fabrizio Giordanetto, Head Medicinal Chemistry, D.E. Shaw Research
14:05-14:35
A Small-Molecule Inhibitor of C5 Complement Protein 
Keith Jendza, Scientific Technical Leader I, Novartis
14:35-15:05
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres 
Joy Yang, Scientist, Pfizer
15:05-15:35
Computational Evaluation of PROTAC-Mediated Protein Degradation: Case Studies and Recent Developments 
Michael Drummond, Scientific Applications Manager, Chemical Computing Group
15:35-16:05
Afternoon Break
Chair: Matt Lucas, Black Diamond Therapeutics
16:05-16:35
An Iterative Scaffold-Hopping Strategy for The Design of Selective PI3K-δ Inhibitors 
Xavier Fradera, Associate Principal Scientist, Merck
16:35-17:05
Ligand-based Design of a Selective Antagonist of TRPA1 That Demonstrates Potent In Vivo Activity 
Laurie Schenkel, Associate Director, Ribon Therapeutics
17:05-17:35
Discovery of JAK1 Selective Kinase Inhibitor, AZD4205 
Qibin Su, Associate Principal Scientist, AstraZeneca
17:35-18:05
Multiparameter Optimization in Drug Discovery 
Istvan Enyedy, Principal Scientist, Biogen
18:05-18:10
Closing Remarks: Chris Williams, CCG
18:10-19:10
Social Reception