2026 to Date
| The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers Nature Cancer (2026) doi |
| Discovery and Characterization of a First-In-Class HCK/BTK PROTAC DFCI-002-06 for the Treatment of MYD88 Mutated B Cell Malignancies Journal of Medicinal Chemistry (2026) doi |
| Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies Journal of Medicinal Chemistry (2026) doi |
| Directed evolution of shikimate dehydrogenase to improve non-natural cofactor preference International Journal of Biological Macromolecules 337 (2026) 149470 doi |
| A droplet microfluidics-based platform for generating target-specific, natively-paired immune libraries and identifying potent and developable antibodies Scientific Reports (2026) doi |
| 2'-Nitroflavone targets PARP1 and alters cytoskeleton to inhibit triple-negative breast cancer progression Scientific Reports (2026) doi |
| Discovery of thiadiazole-based small-molecule inhibitors of SARS-CoV-2 spike-ACE2 interaction through integrated computational prediction and experimental validation Scientific Reports (2026) doi |
| L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling Bioorganic Chemistry 169 (2026) 109418 doi |
| Synthesis and mechanistic exploration of novel oxadiazole–thiadiazinone frameworks: DFT, pathway-oriented docking and enzyme kinetics targeting diabetes mellitus Journal of Molecular Structure 1350 (2026) 144028 doi |
| Targeting HDAC3 dynamics: Allosteric role of Phe200 in inhibitor binding and breast cancer therapy Journal of Molecular Graphics and Modelling 142 (2026) 109226 doi |
| ACE1-targeting peptide Acein ameliorates UV-induced skin damage and aging in vivo and in vitro via downregulation of the pro-aging factor CLEC4G Biochemical Pharmacology 243 (2026) 117542 doi |
| Structural characterization of a L-dehydroascorbic acid–L-homocysteine thiolactone reaction product: Intracellular formation in neuronal cells Biochimica et Biophysica Acta (BBA) 1870 (1) (2026) 130882 doi |
| DAT-delivered astaxanthin reprograms adipogenesis through RhoGDI1 dephosphorylation at Ser174 and RhoA/FAK/ERK1/2 cascade suppression Biomaterials 329 (2026) 123979 doi |
| Sequence-dependent RNA cleavage by the 8–17 DNAzyme: Identification of preferred tetranucleotide motifs Bioorganic & Medicinal Chemistry 134 (2026) 118520 doi |
| Discovery of a macrocyclic FAK inhibitor GZD-257 for treatment of glioblastoma Bioorganic & Medicinal Chemistry Letters 130 (2026) 130424 doi |
| Structural diversity of aldehydes determines covalent versus non-covalent inhibition mechanisms against steroid 5α-reductase type 1: Species-specific differences and preliminary structure-activity relationships Chemico-Biological Interactions 424 (2026) 111888 doi |
| Molecular dynamics study of M-Trifluoromethyl diphenyl diselenide binding to the μ-opioid receptor: A computational perspective on morphine-induced tolerance Computational Biology and Chemistry 120 (2026) 108659 doi |
| Mathematical and Artificial Intelligence Techniques in Modern Drug Discovery: A Review Drug Development Research 87 (1) (2026) e70212 doi |
| Pharmacological Evaluation of Novel N- and C-Modified Peptide Analogues of VV-hemorphin-5 and VV-hemorphin-7 as Potential Agents With Anti-Seizure Activity Drug Development Research 87 (1) (2026) e70209 doi |
| Integrative discovery of novel antioxidant peptides from bovine hide via peptidomics-guided molecular simulation, quantum chemistry, and experimental validation Food Research International 226 (2026) 118196 doi |
| From bench to brain: novel thieno-oxazine hybrids as potent pleiotropic anti-Alzheimer’s agents with in vivo/in vitro validation and in silico insights Journal of Enzyme Inhibition and Medicinal Chemistry 41 (1) (2026) 2598741 doi |
| Divergent roles of crassifolin B and cyperenoic acid from Gentiana kurroo in regulating adipocyte differentiation in 3T3-L1 cells through PPARγ and MAPK pathways Journal of Ethnopharmacology 357 (2026) 120923 doi |
| Polypyridyl Ru(II) tamoxifen analogues: Estrogen receptor-targeted dual photodynamic and chemotherapeutic agents Journal of Inorganic Biochemistry 277 (2026) 113202 doi |
| Imeglimin ameliorates MASLD by targeting PEN2 to activate AMPK pathway Metabolism 175 (2026) 156458 doi |
| METTL1-mediated m7G methylation of FoxO1 regulates lipid metabolism in metabolic dysfunction-associated fatty liver disease Metabolism 174 (2026) 156420 doi |
| Virtual screening and activity evaluation of novel ecdysone analogues targeting overlapping binding pockets in Lepidoptera ecdysone receptor Pesticide Biochemistry and Physiology 216 (2026) 106723 doi |
| Assessment of resistance risk and molecular basis of bixafen in Alternaria alternata causing early blight of potato in China Pesticide Biochemistry and Physiology 216 (2026) 106735 doi |
| Graveoumarins A–C: chiral resolution, absolute configuration, and anticoagulant/anti-inflammatory activities of 3′-methyl-3′-butenyl coumarins from ruta graveolens L Pharmaceutical Biology 64 (1) (2026) 17-26 doi |
| From Bolinaquinone, a Marine Hydroxyquinone sesquiterpene, to Naphthoquinones with Clathrin inhibitory effects RSC Medicinal Chemistry (2026) doi |
| Integration of Multiple Mass Spectrometry Techniques and Molecular Network Analysis With Bioinformatics Approaches Revealed the Mechanism of Jiuwei Xifeng Granules in the Treatment of Tourette's Syndrome Rapid Communications in Mass Spectrometry 40 (2) (2026) e10156 doi |
| Metabolic activation of pentachlorophenol: TCBQ as a potent inhibitor of gonadal steroidogenesis via 3β-hydroxysteroid dehydrogenase NAD+ binding-site thiolalkylation Reproductive Toxicology 139 (2026) 109115 doi |
| Glabridin attenuates dibutyl phthalate-induced testicular toxicity via regulating oxidative stress, inflammation, apoptosis, and Wnt/β-catenin pathway Tissue and Cell 98 (2026) 103223 doi |
| Antiparasitic agent emodepside exerts cytotoxicity in human corneal stromal cells by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1) Toxicology 519 (2026) 154334 doi |
| Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against Streptococcus pyogenes Virulence 17 (1) (2026) 2609393 doi |
| Chapter 4 Interaction of Food Macromolecules Academic Press (2026) 69-80 doi |
| Computational Methods Applied to Drug Discovery of Protein–Protein Interaction Systems Targeting Protein–Protein Interactions for Drug Discovery (2026) 389-408 doi |
| Synergistic Effect of Nanoplastics and GenX on Human Serum Albumin: The Role of Protein Corona Formation and Co-Adsorption Toxics 14 (1) (2026) 12 doi |